The Montreal Protocol on Substances that Deplete the Ozone Layer of the Vienna Convention has been ratified by all 33 countries of Latin America and the Caribbean. Since its entry into force in 1989 and in response to technological advances, the Protocol has been adjusted six times and modified four. Both the Convention and the Protocol (including the four amendments) have universal participation. The Protocol’s objective is to establish limits in the production and consumption of the principal chemicals that destroy the ozone layer that protects the Earth. The Protocol also contributes to global efforts to combat climate change given that most ozone-depleting substances eliminated though the Protocol are also significant greenhouse gases.